Publications by authors named "A D Genazzani"
Aims: In Europe, the European Medicines Agency (EMA) has an accelerated pathway to prioritize approval of medicines. Approved drugs are then assessed by Health Technology Assessment (HTA) bodies before being made available to patients. The aim of the study was to evaluate the characteristics of the drugs admitted to the EMA accelerated assessment (AA) and scrutinize the downstream HTA procedures regarding these medicines and the final assessment regarding added therapeutic value (ATV).
View Article and Find Full Text PDFThe optimal contraception dosing strategy proposed by Gavina et al. recently is a commendable attempt to model a complex physiological process with potenial to apply to real-life data. However, there is a need to take into account the real challenges that arise when moving from the theory to its practical application, and it is important that lessons learnt from clinical studies be taken into consideration in any theoretical modelling.
View Article and Find Full Text PDFBackground: Medical cannabis (MC) has gained traction in oncology for managing cancer-related symptoms, but its integration faces challenges due to limited evidence, inconsistent guidelines, and varied legal frameworks.
Methods: The TASMAN study aimed to assess the knowledge, attitudes, and practices of oncologists and palliative care providers globally regarding MC use in cancer care. A survey of healthcare providers from diverse regions and income levels was conducted.
Article Synopsis
- - Tumour angiogenesis is crucial for supplying malignant cells with oxygen and nutrients, facilitating their invasion and spread, often resulting in the formation of disorganized and leaky blood vessels due to cytokine activity.
- - Nicotinamide phosphoribosyltransferase (eNAMPT) is elevated in many cancers, acting not only as a necessary enzyme for energy production but also as a pro-inflammatory cytokine that correlates with cancer aggressiveness and prognosis, especially in breast cancer.
- - In triple-negative breast cancer, eNAMPT promotes angiogenesis and metastasis by attracting NG2 pericytes and activating pro-inflammatory signaling, with potential therapeutic effects demonstrated by neutralizing eNAMPT with an antibody, pointing towards new anti-
Article Synopsis
- - The study investigates how calcium (Ca) transfer between the endoplasmic reticulum (ER) and mitochondria, crucial for energy production, is affected by the distance between these organelles, particularly in the context of Parkinson's disease (PD).
- - Researchers found that a specific distance of approximately 20 nm between ER and mitochondria enhances Ca transfer and supports optimal mitochondrial function, highlighting the importance of maintaining this distance.
- - In astrocytes derived from PD patients, the natural distance for efficient Ca transfer was reduced, leading to decreased mitochondrial function, but restoring the 20 nm distance improved Ca uptake, suggesting new ways to manage mitochondrial health.