Publications by authors named "A D Frankel"
The accuracy of the latest generation Dexcom G7 sensors in individuals with diabetes undergoing hemodialysis has not previously been investigated. Participants with diabetes undergoing hemodialysis were recruited, with paired sensor glucose from Dexcom G7 recorded with plasma glucose analyzed in the laboratory, as well as the Freestyle Precision Pro glucometer and EKF Biosen C-Line analyzer. Ten adults (median age 64.
View Article and Find Full Text PDFChronic disease progression models are available for several highly prevalent conditions. For chronic kidney disease (CKD), the scope of existing progression models is limited to the risk of kidney failure and major cardiovascular (CV) events. The aim of this project was to develop a comprehensive CKD progression model (CKD-PM) that simulates the risk of CKD progression and a broad range of complications in patients with CKD.
View Article and Find Full Text PDFCurrent management of chronic kidney disease in type-2 diabetes-A tiered approach: An overview of the joint Association of British Clinical Diabetologists and UK Kidney Association (ABCD-UKKA) guidelines.
Diabet Med
February 2025
Article Synopsis
- A significant number of people with diabetes develop chronic kidney disease (CKD), which often leads to end-stage kidney disease (ESKD) and is highly associated with cardiovascular disease (CVD) mortality.
- Managing modifiable risk factors, such as hyperglycemia and hypertension, along with treating dyslipidemia is vital for patients with type 2 diabetes and CKD to reduce the risk of CVD.
- Recent clinical trials demonstrate that medications like SGLT-2 inhibitors and GLP-1 receptor agonists can help protect kidney function in these patients, informing updated clinical practice guidelines for healthcare professionals.
Article Synopsis
- Crm1 is a key nuclear exportin responsible for transporting over 1000 human proteins, including RNP complexes, but the interaction mechanism with these cargos is not fully understood.
- The study reveals a cryo-electron microscopy structure of the HIV-1 nuclear export complex, showcasing how the Rev protein binds to a new site on Crm1 that stabilizes its dimeric form and positions nuclear export sequences (NESs) for effective transport.
- Research findings indicate that Crm1 has multiple recognition sites for different types of cargo, emphasizing its ability to interact with a diverse range of proteins and RNPs.