Publications by authors named "A D Essien"
Article Synopsis
- - The study aimed to assess how effective and safe teriparatide is for treating postmenopausal osteoporosis compared to other treatments, using data from randomized controlled trials up to January 2023.
- - Analysis of 23 trials revealed that teriparatide significantly improved bone mineral density (BMD) in the lumbar spine and femoral neck, but not in total hip and radial BMD, with an increase in certain bone turnover markers.
- - Although teriparatide treatment led to a higher risk of adverse events, it also significantly reduced fracture rates, suggesting that it is beneficial for high-risk osteoporosis patients, while more research is needed to explore its long-term effects.
Sarcopenia is an aging-related skeletal disease characterized by decreased muscle mass, strength, and physical function, severely affecting the quality of life (QoL) of the elderly population. Sirtuin 1 (SIRT1), as a nicotinamide adenine dinucleotide (NAD+)-dependent histone deacetylases, has been reported to participate in various aging-related signaling pathways and exert protective effect on many human diseases. SIRT1 functioned as an important role in the occurrence and progression of sarcopenia through regulating key pathways related to protein homeostasis, apoptosis, mitochondrial dysfunction, insulin resistance and autophagy in skeletal muscle, including SIRT1/Forkhead Box O (FoxO), AMP-activated protein kinase (AMPK)/SIRT1/nuclear factor κB (NF-κB), SIRT1/p53, AMPK/SIRT1/peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α), and SIRT1/live kinase B1 (LKB1)/AMPK pathways.
View Article and Find Full Text PDFPurpose: To compare the accuracy of 3-dimensional (3D) magnetic resonance imaging (MRI) with that of 3D computed tomography (CT) in evaluating glenoid bone loss (GBL).
Methods: This review aligned with Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines. PubMed, the Cochrane Library, Embase, and Web of Science were obtained from data inception to August 28, 2023.
Sustainable drainage systems (SuDS) are nature-based methods of managing urban stormwater runoff. Although they are widely used, some SuDS, such as highway filter drains (HFDs), are understudied with respect to sizing and performance. For the first time, we developed an analytical probabilistic model (APM) that can be used to design and estimate the hydrologic performance of HFDs.
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