An Evaluation of Career Opportunity Readiness Experience (CORE): An Enhancement to Supported Employment for Transition Age Youth with Serious Mental Health Diagnoses.

Transition-age youth (TAY) diagnosed with serious mental health diagnoses have low employment rates. Supported Employment (SE) is a widely adopted evidence-based approach. However, SE engagement and outcomes are mixed with TAY, who have unique developmental needs.

Perspectives in cattle reproduction for the next 20 years - A European context.

Following a significant increase in herd and farm sizes after the removal of milk quotas in Europe, the past 10 years have seen a slight yet steady decline in the population of cattle. This includes a reduction of approximately 5 % in dairy and beef cattle. This trend is driven by various factors, such as changing market demands, economic shifts, and sustainability challenges in the livestock sector.

Targeting Endogenous Tau in Seeded Tauopathy Models Inhibits Tau Spread.

The transmission of tau pathology has been proposed as one of the major mechanisms for the spatiotemporal spreading of tau pathology in neurodegenerative diseases. Over the last decade, studies have demonstrated that targeting total or pathological tau using tau antibodies can mitigate the development of tau pathology in tauopathy or Alzheimer's disease (AD) mouse models, and multiple tau immunotherapy agents have progressed to clinical trials. Tau antibodies are believed to inhibit the internalization of pathologic seeds and/or block seed elongation after seed internalization.

Ejectosome of bacteriophage ΦM1.

Podophages that infect gram-negative bacteria, such as pathogen ΦM1, encode tail assemblies too short to extend across the complex gram-negative cell wall. To overcome this, podophages encode a large protein complex (ejectosome) packaged inside the viral capsid and correspondingly ejected during infection to form a transient channel that spans the periplasmic space. Here, we describe the ejectosome of bacteriophage ΦM1 to a resolution of 3.

Incidence and timing of pregnancy loss following timed artificial insemination or timed embryo transfer with a fresh or frozen in vitro-produced embryo.

The aim of this study was to characterize the incidence and timing of pregnancy loss from service event (timed artificial insemination or timed embryo transfer) to parturition. Lactating Holstein-Friesian cows were randomly assigned to receive either AI (n = 243) or embryo transfer (ET, n = 863) with a fresh or frozen in vitro-produced blastocyst derived from oocytes collected from the ovaries of elite dairy donors (n = 14 Holstein-Friesian and n = 8 Jersey) and elite beef donors (n = 21 Angus) using transvaginal ovum pick-up. In addition, oocytes were collected from the ovaries of beef heifers of known pedigree following slaughter at a commercial abattoir (n = 119).