Publications by authors named "A D Carlos"
MDM2 inhibitors are promising therapeutics for acute myeloid leukemia (AML) with wild-type TP53. Through an integrated analysis of functional genomic data from primary patient samples, we found that an MDM2 inhibitor idasanutlin, like venetoclax, is ineffective against monocytic leukemia (FAB M4/M5). To dissect the underlying resistance mechanisms, we explored both intrinsic and extrinsic factors.
View Article and Find Full Text PDFContext: This study aims to provide data on the reliability and validity of an adapted Spanish version of the Athlete Psychological Strain Questionnaire (APSQ) when administered to Spanish athletes.
Design: A cross-sectional study was developed.
Methods: Data were collected from 128 athletes (males n = 71; females n = 57).
Organ-on-a-chip: Quo vademus? Applications and regulatory status.
Colloids Surf B Biointerfaces
May 2025
Article Synopsis
- Organ-on-a-chip systems (or microphysiological systems) are advanced bioengineering tools designed to replicate human organ functions, boosting drug discovery and providing insights into disease.
- These systems create 3D environments that can mimic specific human tissues and disease states, allowing researchers to study drug responses, safety, and disease progression more effectively.
- They also hold future potential for personalized medicine by simulating the unique physiological responses of individual patients, guiding treatment strategies for better health outcomes.
Introduction: Greater white matter hyperintensities (WMHs) on magnetic resonance imaging (MRI) are seen with transactive response DNA-binding protein 43 (TDP-43) pathology in frontotemporal lobar degeneration (FTLD-TDP). WMH associations with TDP-43 pathology in Alzheimer's disease (AD-TDP) remain unclear.
Methods: A total of 157 participants from Mayo Clinic Rochester with autopsy-confirmed AD, known TDP-43 status, and antemortem fluid-attenuated inversion recovery (FLAIR) MRI were included.