Publications by authors named "A D Bharucha"
Objective: To assess whether the mode and formatting of invitations affect enrollment in a large, decentralized study.
Patients And Methods: Between July 1, 2022, and October 30, 2022, we prospectively compared various approaches to enroll patients in the Tapestry DNA Sequencing Research Study, a decentralized exome-sequencing study. In phase 1, patients were randomized to receive invitations via the electronic health record (EHR) patient portal or email (cohort 1, 69,852 patients).
Article Synopsis
- The study investigated how ondansetron affects patients with diabetic gastroenteropathy (DGE) compared to a placebo.
- Patients took ondansetron or a placebo for 4 weeks, and their symptoms and gastric emptying were monitored through various methods.
- Ondansetron reduced feelings of fullness and belching during lipid infusions but did not significantly affect daily symptoms compared to placebo, although some patients showed potential for symptom improvement when ondansetron was effective during the lipid challenge.
The Navitor transcatheter heart valve (THV) is the latest iteration of the Portico self-expanding valve system. Early prospective studies have shown promising outcomes, however, there is a lack of complementary 'real-world' data. This study aimed to assess early safety and efficacy outcomes of the Navitor THV using registry data from 6 high-volume United Kingdom transcatheter aortic valve replacement (TAVR) centers.
View Article and Find Full Text PDFSmall intestinal bacterial overgrowth in diabetic gastroenteropathy.
Neurogastroenterol Motil
July 2024
Background: Although diabetic gastroenteropathy (DGE) is associated with small intestinal bacterial overgrowth (SIBO), most studies have evaluated SIBO with a hydrogen breath test, which may be affected by altered transit in DGE. The risk factors for the consequences of SIBO in DGE are poorly understood. We aimed to evaluate the prevalence of, risk factors for, and gastrointestinal symptoms associated with SIBO in patients with DGE.
View Article and Find Full Text PDFBackground And Aims: Up to 50% of patients with Parkinson disease have constipation (PD-C), but the prevalence of defecatory disorders caused by rectoanal dyscoordination in PD-C is unknown. We aimed to compare anorectal function of patients with PD-C versus idiopathic chronic constipation (CC).
Methods: Anorectal pressures, rectal sensation, and rectal balloon expulsion time (BET) were measured with high-resolution anorectal manometry (HR-ARM) in patients with PD-C and control patients with CC, matched for age and sex.