Publications by authors named "A D Bachstetter"
Background: Delayed cerebral ischemia (DCI) is a significant complication of aneurysmal subarachnoid hemorrhage (aSAH). This study profiled immune responses after aSAH and evaluated their association with DCI onset.
Methods: Twelve aSAH patients were enrolled.
Article Synopsis
- * Researchers found that aged female mice experienced more significant cognitive deficits and a stronger neuroinflammatory response compared to younger mice following a CHI, indicating a unique aging-TBI signature in white matter.
- * In gray matter, aged mice showed different patterns, including less severe responses and signs of glial degeneration, suggesting that aging affects these injuries differently in various brain regions and highlighting the need for further research on these responses, especially in aging females.
Article Synopsis
- Microglia, particularly dystrophic microglia, are implicated in the progression of Alzheimer's disease (AD), with their structural changes linked to neurodegeneration and aging.
- Recent research indicates that tau proteins and amyloid-β may induce these dystrophic changes, hinting at a connection between these proteins and microglial pathology in AD.
- A study analyzing human brain samples demonstrates a significant increase of dystrophic microglia in early AD-affected regions, suggesting their specific role in AD neuropathology and potential influence on the spread of amyloid-β and tau in the disease.
Background: TAR DNA-Binding Protein 43 (TDP-43) pathological inclusions are a distinctive feature in dozens of neurodegenerative pathologies, including limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC). Prior investigations identified vascular-associated TDP-43-positive micro-lesions, known as "Lin bodies," located on or near the brain capillaries of some individuals with LATE-NC. This study aimed to investigate the relationship between the accumulation of Lin bodies and glial cells in LATE-NC and the potential co-localization with ferritin, a protein associated with iron storage.
View Article and Find Full Text PDFBackground And Purpose: The immune response changes during aging and the progression of Alzheimer's disease (AD) and related dementia (ADRD). Terminally differentiated effector memory T cells (called T) are important during aging and AD due to their cytotoxic phenotype and association with cognitive decline. However, it is not clear if the changes seen in T are specific to AD-related cognitive decline specifically or are more generally correlated with cognitive decline.
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