Towards a European health information system: The BRIDGE Health, InfAct and PHIRI projects.

Background: National health systems in Europe are facing similar challenges - demographic change, a rising burden of disease due to chronic non-communicable diseases, and health inequalities. Comparable health data and knowledge sharing between countries are therefore an important basis for policy decision-making. However, health information in the European Union (EU) is fragmented and approaches to establishing a comprehensive system are largely project-based.

Dengue virus and Zika virus alter endoplasmic reticulum-mitochondria contact sites to regulate respiration and apoptosis.

During infection, dengue virus (DENV) and Zika virus (ZIKV), two (ortho)flaviviruses of public health concern worldwide, induce alterations of mitochondria morphology to favor viral replication, suggesting a viral co-opting of mitochondria functions. Here, we performed an extensive transmission electron microscopy-based quantitative analysis to demonstrate that both DENV and ZIKV alter endoplasmic reticulum-mitochondria contact sites (ERMC). This correlated at the molecular level with an impairment of ERMC tethering protein complexes located at the surface of both organelles.

Genomic Variability Survey in L., with Reference to Four Insular Populations from Eastern Europe.

Cosmopolitan in the western areas of Europe as well as on other continents, the Ilex genus is interesting for its genetic, phenotypic, and biogeographic variabilities. Its insular/local distribution, according to existing data on the periphery of the central and southern European areas, represents a suitable case study with reference to the adaptive plasticity or acclimatization of the L. species to new climatic conditions.

Quercetin Enhances 5-Fluorouracil-Driven Cytotoxicity Dose-Dependently in A375 Human Melanoma Cells.

Cutaneous melanoma (CM) represents a severe skin cancer with a rising incidence at present and limited treatment options. 5-Fluorouracil (5-FU) is widely used, including for CM; however, the innate resistance of this cancer to conventional therapy remains problematic. Quercetin (QUE) is a flavonoid that can sensitize cancer cells to antitumor agents such as 5-FU.