Vaccination of broilers with HVT expressing an Eimeria acervulina antigen improves performance after challenge with Eimeria.

The sequence encoding part of the 100 kDa refractile body protein (Ea1A) from Eimeria acervulina was cloned into the US10 locus of herpesvirus of turkeys (HVT) downstream of LTR promoter. Expression of the fusion protein was shown in vitro. Recombinant HVT showed a delayed and slightly reduced level of viremia compared to the parent strain in SPF chickens as well as in broilers.

The gene downstream of the gC homologue in feline herpes virus type 1 is involved in the expression of virulence.

Feline herpesvirus type 1 (FHV-1) mutants were constructed, carrying a beta-galactosidase marker gene integrated into the region downstream of the gene encoding the homologue of glycoprotein C (gC) of herpes simplex virus type 1. In cell culture, no differences in replication were observed between mutants and the parent FHV-1 strain. However, in experimentally infected cats, mutants caused fewer clinical signs after oronasal administration although they replicated to the same extent as the parental strain.

[Fracture incidence in 803 women with postmenopausal osteoporosis under drug treatment].

In a survey of cases of confirmed postmenopausal osteoporosis, 803 women were asked to complete a questionnaire on radiologically confirmed fractures sustained prior to and during drug therapy. Under monotherapy (fluoride or calcium, n = 92) the number of peripheral and central fractures was 54% and 49% lower, respectively. The corresponding figures with two substances (fluoride and calcium, n = 226) were 58% and 60%, with three substances (fluoride, calcium and estrogens or Vitamin D, n = 223) 83% and 72%, and with four substances (n = 254) 85% and 75%.