Publications by authors named "A Crino"
Article Synopsis
- Prader-Willi syndrome (PWS) is a genetic disorder caused by different problems on chromosome 15, affecting how some genes work.
- People with PWS often feel super hungry all the time, can become very overweight, and may have other health and learning issues.
- The review explores how different genetic causes of PWS can lead to specific health problems and looks for ways to improve diagnosis and treatments for those affected.
Background: Prader-Willi syndrome (PWS) is a rare, complex, genetic disorder characterized by hyperphagia, hypotonia, delayed psychomotor development, low muscle mass and hypothalamic dysfunction. Adults with PWS often have obesity, hypertension and type 2 diabetes mellitus (DM2), known risk factors for cardiovascular disease (CVD) and chronic kidney disease (CKD). Early symptoms of CVD and CKD may be masked by intellectual disability and inability to express physical complaints.
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- Prader-Willi syndrome (PWS) is a genetic disorder linked to issues with chromosome 15, resulting in symptoms similar to growth hormone deficiency, including short stature and obesity.
- A study involved 12 obese adults with PWS undergoing long-term growth hormone (GH) treatment, revealing reductions in waist circumference and fat mass percentage, alongside increased IGF-I levels.
- Although GH therapy improved body composition, it also led to a slight increase in fasting glucose levels, necessitating ongoing monitoring of glucose metabolism in these patients.