Publications by authors named "A Crinier"
Article Synopsis
- The clinical study investigated the effects of LifeinU™ Bacillus subtilis CU1 (BSCU1) on immune responses in 88 participants across different age groups, aiming to understand how it might improve protection against infections.
- Although BSCU1 did not significantly alter fecal sIgA levels, it positively impacted various markers of the innate immune system, especially in adults and the elderly, by increasing peripheral blood myeloid cells and CD69 expression on monocytes.
- Additionally, the supplementation led to higher production of pro-inflammatory cytokines and improved the ability of monocytes to engulf bacteria, while also reducing levels of certain inflammatory cytokines in older adults, suggesting potential benefits for overall immune health.
Innate lymphoid cells (ILCs) are tissue-resident lymphocytes differing from conventional T lymphocytes in having no antigen-specific receptors. ILCs include natural killer (NK) cells, helper-like ILC1s, ILC2s, and ILC3s, and lymphoid tissue-inducer (LTi) cells. Tumor ILCs are frequently found in various cancers, but their roles in cancer immunity and immunotherapy remain largely unclear.
View Article and Find Full Text PDFLymphocytes are essential for microbial immunity, tumor surveillance, and tissue homeostasis. However, the in vivo development and function of helper-like innate lymphoid cells (ILCs) in humans remain much less well understood than those of T, B, and NK cells. We monitored hematopoietic stem cell transplantation (HSCT) to determine the kinetics of ILC development in both children and adults.
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