Publications by authors named "A Cretti"
Thiamine is a crucial cofactor involved in the maintenance of carbohydrate metabolism and participates in multiple cellular metabolic processes. Although thiamine can be obtained from various food sources, some common food groups are deficient in thiamine, and it can be denatured by high temperature and pH. Additionally, different drugs can alter thiamine metabolism.
View Article and Find Full Text PDFBackground And Aims: The relatives role of each component of the glucose-insulin system in determining hyperglycemia in type 2 diabetes is still under debate. Metabolic Control Analysis (MCA) quantifies the control exerted by each component of a system on a variable of interest, by computing the relevant coefficients of control (CCs), which are systemic properties. We applied MCA to the intravenous glucose tolerance test (IVGTT) to quantify the CCs of the main components of the glucose-insulin system on intravenous glucose tolerance.
View Article and Find Full Text PDFBackground: The essential fatty acids and their long-chain polyunsaturated derivatives (LC PUFAs) are important for the growth and maturation of the fetal organism.
Objective: The aim of a study was to assess the profile of the essential fatty acids and their LC PUFAs in the blood and adipose tissue of pregnant women and in the cord blood after elective caesarean section.
Design: The study group comprised 36 women and 38 their full-term babies born after elective caesarean section.
Article Synopsis
- The study investigates how hyperinsulinemia affects endothelial function in large arteries, which is important for understanding the risk of atherosclerosis in insulin-resistant individuals.
- Twenty-five healthy participants were subjected to various conditions of insulin levels, with assessments of both endothelium-dependent and independent vasodilation through ultrasound techniques.
- Results showed that hyperinsulinemia diminishes endothelium-dependent vasodilation but not endothelium-independent vasodilation, and the antioxidant vitamin C can restore endothelial function, suggesting oxidative stress may mediate these effects.
The ACE gene is a candidate gene for cardiovascular disease. Endothelial dysfunction is considered an intermediate phenotype in the pathogenesis of hypertension and atherosclerosis. We evaluated the role of ACE gene polymorphism in endothelial function of young healthy humans.
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