Publications by authors named "A Cowley"
Background: Hypertension or elevated blood pressure (BP) is a worldwide clinical challenge and the leading primary risk factor for kidney dysfunctions, heart failure, and cerebrovascular disease. The kidney is a central regulator of BP by maintaining sodium-water balance. Multiple genome-wide association studies revealed that BP is a heritable quantitative trait, modulated by several genetic, epigenetic, and environmental factors.
View Article and Find Full Text PDFBackground: Type 2 diabetes (T2D) leads to cardiovascular remodeling, and heart failure has emerged as a major complication of T2D. There is a limited understanding of the impact of T2D on the right heart. This study aimed to assess subclinical right heart alterations and their contribution to aerobic exercise capacity (peak oxygen consumption; peak VO) in adults with T2D.
View Article and Find Full Text PDFArterioles are small blood vessels located just upstream of capillaries in nearly all tissues. The constriction and dilation of arterioles regulate tissue perfusion and are primary determinants of systemic blood pressure (BP). Abnormalities in arterioles are central to the development of major diseases such as hypertension, stroke, and microvascular complications of diabetes.
View Article and Find Full Text PDFArticle Synopsis
- - Studies indicate that blood flow to the renal medulla is crucial for regulating blood pressure and pressure-natriuresis.
- - Research in rats suggests that proper medullary blood flow is essential for balancing blood pressure and that reduced blood flow can lead to hypertension.
- - Enhanced blood flow in the medulla can lower hypertension, and nitric oxide production in this area is vital for protecting against damage caused by various harmful agents.
Background: There is a need to develop research focussed healthcare professionals with the clinical experience and academic skills to meet the needs of a diverse population. Yet, healthcare professionals from ethnic minority backgrounds are often faced with personal, structural or organisational barriers, which prevent them from accessing and applying for development opportunities.
Aim: To undertake an evaluation of the Step into Clinical Academic Careers' programme.