Publications by authors named "A Cottereau"

Classic Hodgkin lymphoma (HL) is a distinct entity among hematological malignancies of B-cell origin. It is characterized by its unique histopathological features and generally favorable prognosis. Over the years, advancements in understanding its pathogenesis, coupled with refined diagnostic and evaluation modalities, as well as therapeutic strategies, have significantly transformed the landscape of HL management.

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Understanding the differences between prognostic and predictive indices is imperative for medical research advances. We have developed a new prognostic measure that will identify the strengths, limitations, and potential applications in clinical practice.

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Article Synopsis
  • Primary testicular lymphoma (PTL) is a rare form of diffuse large B-cell lymphoma (DLBCL), making up 1%-2% of DLBCL cases and is linked to poor outcomes due to high rates of central nervous system relapse.
  • In a study of 15 patients (5 with PTL and 10 with DLBCL involving the testes), treatment with high-dose methotrexate and R-CHOP showed a 73% complete response (CR) rate overall, with 100% CR in PTL patients and only 55% in DLBCL-T patients.
  • The molecular similarities between PTL and primary CNS lymphoma (PCNSL) indicate they may have common origins, highlighting
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Total metabolic tumor volume (TMTV) is prognostic in lymphoma. However, cutoff values for risk stratification vary markedly, according to the tumor delineation method used. We aimed to create a standardized TMTV benchmark dataset allowing TMTV to be tested and applied as a reproducible biomarker.

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Everolimus and peptide receptor radionuclide therapy (PRRT, Lu-DOTATATE) are 2 treatments recommended in guidelines for gastroenteropancreatic metastatic neuroendocrine tumors. However, the best treatment sequence remains unknown. We designed a retrospective multicenter study that included patients from the national prospective database of the Groupe d'Étude des Tumeurs Endocrines who had been treated using everolimus and PRRT between April 2004 and October 2022.

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