Publications by authors named "A Cosmidis"
Article Synopsis
- The study aimed to evaluate factors affecting long-term quality of life (QoL) and patient concerns in elderly patients (70+) with oral or oropharyngeal cancer after surgery and reconstruction.
- Sixty-four disease-free patients completed various QoL questionnaires and assessments, revealing preserved long-term QoL but persistent issues such as fatigue, oral function disorders, and concerns about salivation and swallowing.
- The results indicated that an increase in patient concerns correlated with lower QoL, highlighting the need for effective dental, psychological, and nutritional support in managing elderly OOPC patients.
Objectives: In patients with N3 head and neck squamous cell carcinoma (HNSCC), N3 disease is associated with high regional relapse and metastatic risks. Patients with resectable N3 disease have better prognosis although their metastatic risk may be similar as in patients with unresectable disease. Neoadjuvant chemotherapy has been associated with lower metastatic rates, but N3 patients may die of rapid locoregional progression.
View Article and Find Full Text PDFBackground: The prognosis of advanced nodal (N3) squamous cell carcinoma of the head and neck (HNSCC) is poor. We investigated whether surgery or radiotherapy of early (T1-2) primary stage HSNCC is preferable to limit the overall morbidity after upfront neck dissection (uND) for N3 disease.
Methods: This retrospective multicentric Groupe d'Étude des Tumeurs de la Tête Et du Cou study included patients undergoing uND and surgery or radiotherapy of their primary.
Hormographiella aspergillata is a rare causative agent of invasive filamentous breakthrough infection, mostly arising after echinocandin exposure. We report a neutropenic patient who developed a severe sino-orbito-cerebral H. aspergillata infection while receiving empirical caspofungin, successfully controlled by an aggressive strategy associating surgical debridement and combined high-dose regimen of antifungal drugs.
View Article and Find Full Text PDFBackground: No specific study has focused on patients with metastatic squamous cell carcinoma of the head and neck (SCCHN) at diagnosis. Due to high response rates of induction chemotherapy in chemo-naïve patients with localized disease, their prognosis should be better than patients with recurrent disease.
Methods: From January 1, 2008 to July 1, 2012, we retrospectively collected all patients' records with SCCHN diagnosed as metastatic.