Synergistic polytherapy for the broad-spectrum treatment of chemically-induced seizures in rats.

Chemically-induced seizures, as a result of exposure to a neurotoxic compound, present a serious health concern. Compounds can elicit seizure activity through disruption of neuronal signaling by neurotransmitters, either by mimicking, modulating or antagonizing their action at the receptor or interfering with their metabolism. Benzodiazepines, such as diazepam and midazolam, and barbiturates are the mainstay of treatment of seizures.

Breakthrough-induced loop formation in evolving transport networks.

Transport networks, such as vasculature or river networks, provide key functions in organisms and the environment. They usually contain loops whose significance for the stability and robustness of the network is well documented. However, the dynamics of their formation is usually not considered.

A review of pollution-based real-time modelling and control for sewage systems.

Conventional solutions for wastewater collection focus on reducing overflow events in the sewage network, which can be achieved by adapting sewer infrastructure or, a more cost-effective alternative, by implementing a non-engineering management solution. The state-of-the-art solution is centered on Real-Time Control (RTC), which is already resulting in a positive impact on the environment by decreasing the volume of wastewater being discharged into receiving waters. Researchers have been continuing efforts towards upgrading RTC solutions for sewage systems and a new approach, although rudimentary, was introduced in 1997, known as Pollution-based RTC (P-RTC), which added water quality (concentration or load) information explicitly within the RTC algorithm.

CD163 Macrophages Induce Endothelial-to-Mesenchymal Transition in Atheroma.

Background: Cell phenotype switching is increasingly being recognized in atherosclerosis. However, our understanding of the exact stimuli for such cellular transformations and their significance for human atherosclerosis is still evolving. Intraplaque hemorrhage is thought to be a major contributor to plaque progression in part by stimulating the influx of CD163 macrophages.

Comparison of thrombogenicity in different types of drug-eluting stents during transition from DAPT to SAPT.

Background: During the transition from dual antiplatelet therapy (DAPT) to single antiplatelet therapy (SAPT), previous studies have raised concerns about a rebound effect. We compared platelet and inflammatory cell adhesion on different types of stents in the setting of clopidogrel presence and withdrawal.

Methods: In Experiment 1, three pigs were administered with DAPT, that is, clopidogrel and acetylsalicylic acid (ASA), for 7 days.