Publications by authors named "A Corma-Gomez"
Impact of Nonalcoholic Fatty Liver Disease on the Survival of People Living With HIV.
Aliment Pharmacol Ther
February 2025
Background: Nonalcoholic fatty liver disease (NAFLD) is an increasing concern for people living with HIV (PLWH). However, information on the impact of NAFLD on the prognosis of PLWH is very scarce.
Aims: To investigate the influence of NAFLD on the overall and liver-related mortality in PLWH.
Background: In patients with hepatitis C virus (HCV) chronic infection and advanced liver disease, the impact of human immunodeficiency virus (HIV) coinfection on the clinical outcome after sustained virological response (SVR) has not been sufficiently clarified. The aim of this study was to compare the mortality after SVR of patients bearing HCV chronic infection and advanced liver fibrosis, with and without HIV-coinfection after a prolonged follow-up.
Methods: This was a prospective multicenter cohort study including individuals with HIV/HCV-coinfection and patients with HCV-monoinfection from Spain, fulfilling: 1) Liver stiffness (LS) ≥9.
Article Synopsis
- - The study investigates how HIV affects the severity of mpox outcomes in a large group of patients from 18 hospitals in Spain, focusing on factors like duration of illness and the presence of complications.
- - Out of 1,823 patients with PCR-confirmed mpox, around 43% were people living with HIV, with a significant portion having uncontrolled viral loads, leading to higher rates of long or complicated mpox.
- - The findings suggest that individuals with uncontrolled HIV are at increased risk for severe mpox complications, highlighting the need for timely HIV testing and immediate antiretroviral therapy for those diagnosed.
Article Synopsis
- - Microglial dysfunction is linked to Alzheimer's disease (AD), with a focus on a variant affecting the SIRPβ1 receptor that regulates the clearance of amyloid-β (Aβ).
- - The study found that a specific insertion in the SIRPβ1 gene alters protein function, increasing the risk of AD and affecting cognitive decline rates in patients with mild cognitive impairment.
- - Results suggest that this SIRPβ1 variant could influence microglial responses to Aβ and may serve as a potential target for treatment strategies that involve the TREM2-TYROBP pathway.