Publications by authors named "A Coretti"
The computer simulation of many molecular processes is complicated by long timescales caused by rare transitions between long-lived states. Here, we propose a new approach to simulate such rare events, which combines transition path sampling with enhanced exploration of configuration space. The method relies on exchange moves between configuration and trajectory space, carried out based on a generalized ensemble.
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- The study investigates bronchiolitis-related hospitalizations in infants from Sept 2018 to March 2023 across six Italian hospitals, noting a significant rebound in cases post-COVID-19 lockdowns.
- In the winter of 2022-2023, there were 953 hospitalizations, a 70% increase from the previous year, with longer hospital stays and more patients needing invasive respiratory support.
- Coinfections also rose, highlighted by a prevalence of 42% this winter, indicating a trend towards more severe bronchiolitis cases compared to the past five years.
Background: Aortic arch malformations (AAMs) should be suspected in the presence of persistent respiratory symptoms despite medical treatment or feeding problems at the pediatric age.
Aim: We report a descriptive cohort of patients with AAMs and the local management protocol applied.
Methods: A total of 59 patients with AAM were retrospectively reviewed.
Abnormalities in position and/or branching of the aortic arch can lead to vascular rings that may cause narrowing of the tracheal lumen due to external compression, or constriction of the oesophagus, causing symptoms that vary in relation to the anatomical vascular pattern and the relationship between these structures. Respiratory morbidity related to external airways compression is a major concern in children affected by vascular rings. Clinical presentation depends on the severity of the tracheal lumen reduction and the presence of associated tracheomalacia.
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