Publications by authors named "A Corbelli"
Amyloid-β1-42 (Aβ42) forms highly stable and insoluble fibrillar structures, representing the principal components of the amyloid plaques present in the brain of Alzheimer's disease (AD) patients. The involvement of Aβ42 in AD-associated neurodegeneration has also been demonstrated, in particular for smaller and soluble aggregates (oligomers). Based on these findings and on genetic evidence, Aβ42 aggregates are considered key players in the pathogenesis of AD and targets for novel therapies.
View Article and Find Full Text PDFNK cells are endowed with tumor killing ability, nevertheless most cancers impair NK cell functionality, and cell-based therapies have limited efficacy in solid tumors. How cancers render NK cell dysfunctional is unclear, and overcoming resistance is an important immune-therapeutic aim. Here, we identify autophagy as a central regulator of NK cell anti-tumor function.
View Article and Find Full Text PDFArticle Synopsis
- * The cryogenic electron microscopy (cryo-EM) analysis of heart-derived AL amyloid (AL59) revealed a unique double-layered structure with a u-shaped core that challenges previous assumptions about the building blocks of amyloid fibrils.
- * Additionally, the study found that collagen VI (COLVI) wraps around the amyloid fibrils, forming a protective helical superstructure, indicating a possible new mechanism for the stability and persistence of amyloid deposits in the body.
Platinum compounds are very active in first-line treatments of ovarian carcinoma. In fact, high rates of complete remission are achieved, but most patients eventually relapse with resistant disease. Many mechanisms underlying the platinum-resistant phenotype have been reported.
View Article and Find Full Text PDFObjective: The objective of this study was to assess the clinical impact and outcome of the SARS-CoV-2 infection on children with cancer or those who received a hematopoietic stem cell transplantation.
Methods: AIEOP (Italian Association of Pediatric Hematology and Oncology) performed a nationwide multicenter observational cohort study, including consecutive patients between April 2020 and November 2022.
Results: Twenty-five Italian centers participated and 455 patients were enrolled.