Publications by authors named "A Coppa"

Aim: To determine the prevalence and characteristics of pulmonary embolism (PE) in patients presenting with haemoptysis. Additionally, we assessed the efficiency and failure rates of different clinical diagnostic algorithms for PE in this patient population.

Methods: We enrolled consecutive adult patients who presented to nine Italian emergency departments with haemoptysis as the primary complaint.

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Etruria contained one of the great early urban civilisations in the Italian peninsula during the first millennium BC, much studied from a cultural, humanities-based, perspective, but relatively little with scientific data, and rarely in combination. We have addressed the unusual location of twenty inhumations found in the sacred heart of the Etruscan city of Tarquinia, focusing on six of these as illustrative, contrasting with the typical contemporary cremations found in cemeteries on the edge of the city. The cultural evidence suggests that the six skeletons were also distinctive in their ritualization and memorialisation.

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Article Synopsis
  • X-ALD (adrenoleukodystrophy) is caused by the loss of the ABCD1 transporter, leading to an accumulation of very-long-chain fatty acids (VLCFAs) that disrupt vital cellular functions for axonal maintenance.
  • Using advanced imaging techniques, researchers found that this VLCFA excess leads to mitochondrial fragmentation in mouse models and patient cells, affecting mitochondrial health.
  • Targeting DRP1, a key protein involved in mitochondrial fission, showed promise in preventing these issues and preserving axonal integrity, indicating potential therapeutic strategies for X-ALD.
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Ancient DNA research in the past decade has revealed that European population structure changed dramatically in the prehistoric period (14,000-3000 years before present, YBP), reflecting the widespread introduction of Neolithic farmer and Bronze Age Steppe ancestries. However, little is known about how population structure changed from the historical period onward (3000 YBP - present). To address this, we collected whole genomes from 204 individuals from Europe and the Mediterranean, many of which are the first historical period genomes from their region (e.

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