Publications by authors named "A Contarino"
Article Synopsis
- Pseudohypoparathyroidism (PHP) is a rare hereditary disorder resulting in hormone resistance, with the study focusing on hypercalcitoninemia in affected patients.
- A retrospective analysis was conducted on 88 children and 43 adults from European endocrinology centers, revealing high rates of hypercalcitoninemia (65.9% in children, 53.5% in adults) with stable calcitonin levels over time and no correlation with parathormone levels.
- The study highlights that hypercalcitoninemia is frequently seen in PHP/iPPSD patients, particularly in specific subtypes, and suggests these patients have a distinctive response to calcium stimulation tests compared to healthy individuals and those with medullary thyroid
Objective: This study aimed to assess the long-term outcome of patients with acromegaly.
Design: This is a multicenter, retrospective, observational study which extends the mean observation period of a previously reported cohort of Italian patients with acromegaly to 15 years of follow-up.
Methods: Only patients from the centers that provided information on the life status of at least 95% of their original cohorts were included.
Article Synopsis
- * Methods: This cross-sectional study was conducted at a specialized care center with 72 participants, measuring various hormonal levels and health conditions, while analyzing genetic variations in blood and adrenal tissue.
- * Results: Among patients with mild autonomous cortisol secretion, 18.8% had germline ARMC5 mutations, but none were found in patients without such secretion; somatic mutations were also identified in some cases without germline variants. No clear clinical indicators were found to predict these genetic mutations.
Current guidelines suggest high-dose steroids as first-line treatment for dysthyroid optic neuropathy (DON). When steroids fail, decompressive surgery is mandatory. We conducted a single-center, retrospective cohort study in a tertiary care combined Thyroid-Eye clinic in Milan, Italy.
View Article and Find Full Text PDFContext: Medullary thyroid carcinoma (MTC) is a malignant neuroendocrine neoplasm that may spread to lymph nodes before the primary tumor is diagnosed; moreover, distant metastases are already present in about 10% of patients at diagnosis. Serum calcitonin (Ctn) usually reflects the spread of disease, thus orienting the extent of surgery and predicting the possibility of biochemical remission. Tumor size and vascular invasion are important prognostic factors, but little is known on the relationship between other histopathological features, such as the presence of a tumor capsule, and long term outcome of MTC.
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