Publications by authors named "A Conforto"
Background: Perivascular Spaces (PVS) are a marker of cerebral small vessel disease (CSVD) that are visible on brain imaging. Larger PVS has been associated with poor quality of life and cognitive impairment post-stroke. However, the association between PVS and post-stroke sensorimotor outcomes has not been investigated.
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- * Researchers analyzed MRI scans from 501 stroke patients to assess regional brain-PAD and lesion loads, discovering that larger stroke lesions correlate with older brain-PAD in the affected areas and younger brain-PAD in the opposite hemisphere.
- * The findings highlight that the severity of stroke damage is linked to poorer motor function, with machine learning models identifying specific brain regions and lesion characteristics as key predictors of motor outcomes.
Article Synopsis
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- The DOI number given is 10.3389/fneur.2023.1251581.
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Article Synopsis
- Chronic motor impairments are a significant disability after stroke, traditionally linked to damage in specific motor system structures like the corticospinal tract.
- This study employs a data-driven approach to analyze chronic motor outcomes in 789 stroke patients, comparing the effectiveness of theory-based biomarkers against new data-driven biomarkers derived from clinical imaging data.
- Results indicate that data-driven biomarkers, especially regional structural disconnection measures, show a stronger correlation with motor outcomes than traditional theory-based measures, while combining demographic factors further enhanced predictive accuracy.
Objective: This study aimed at assessing the alterations in upper limb motor impairment and connectivity between motor areas following the post-stroke delivery of cathodal transcranial direct current stimulation sessions.
Methods: Modifications in the Fugl-Meyer Assessment scores, connectivity between the primary motor cortex of the unaffected and affected hemispheres, and between the primary motor and premotor cortices of the unaffected hemisphere were compared prior to and following six sessions of cathodal transcranial direct current stimulation application in 13 patients (active = 6; sham = 7); this modality targets the primary motor cortex of the unaffected hemisphere early after a stroke.
Results: Clinically relevant distinctions in Fugl-Meyer Assessment scores (≥9 points) were observed more frequently in the Sham Group than in the Active Group.