Endothelial-specific knockout of the scramblase TMEM16F impairs in vivo clot formation.

Objective: Loss of function of the phospholipid scramblase (PLS) TMEM16F results in Scott Syndrome, a hereditary bleeding disorder generally attributed to intrinsic platelet dysfunction. The role of TMEM16F in endothelial cells, however, is not well understood. We sought to test the hypothesis that endothelial TMEM16F contributes to hemostasis by measuring bleeding time and venous clotting in endothelial-specific knockout (ECKO) mice.

A Comparison of In-Person and Telehealth Treatment Modalities using the SpeechVive Device.

Telehealth is increasing popular as a treatment option for people with Parkinson disease (PD). The SpeechVive device is a wearable device that uses the Lombard effect to help patients speak more loudly, slowly, and clearly. This study sought to examine the effectiveness of the device to improve communication in people with PD, delivered over a telehealth modality as compared to in-person, using implementation science design.

Persistent, Private and Mobile genes: a model for gene dynamics in evolving pangenomes.

The pangenome of a species is the set of all genes carried by at least one member of the species. In bacteria, pangenomes can be much larger than the set of genes carried by a single organism. Many questions remain unanswered regarding the evolutionary forces shaping the patterns of presence/absence of genes in pangenomes of a given species.

Recognizing Grace in Grief Through Reflection in Nursing Education: A Qualitative Research Study.

Diverse teaching and learning strategies are needed to develop emotionally intelligent new-graduate nurses who can empathetically care for dying patients. Reflective pedagogy, a teaching strategy that infuses reflection into education, is an effective strategy to enhance nursing student learning, educational enrichment, and emotional intelligence. This project aimed to explore nursing students' thoughts and feelings about end-of-life care through participation in the Grace in Grief intervention.

Single cell RNA-sequencing reveals no evidence for meiotic sex chromosome inactivation in the threespine stickleback fish.

Unlabelled: Sex chromosomes often evolve unique patterns of gene expression in spermatogenesis. In many species, sex-linked genes are downregulated during meiosis in response to asynapsis of the heterogametic sex chromosome pair (meiotic sex chromosome inactivation; MSCI). Our understanding of this process has been limited to a handful of species, including mammals, , and Based on findings from these taxa, MSCI has been viewed as likely a conserved process.