Publications by authors named "A Columbano"
Article Synopsis
- Cancer cells adapt their metabolism to meet energy and growth needs, and this study investigates if similar changes occur in normal liver cells during proliferation.
- The research showed that normal liver cells, when stimulated by lead nitrate, exhibited metabolic traits resembling those of cancer cells, particularly through Nrf2 activation.
- Nrf2 is crucial for these metabolic transformations; however, it did not play a role in metabolic changes when liver proliferation was induced by other methods, highlighting different responses based on the stimuli used.
Article Synopsis
- The study explores how targeting the thyroid hormone receptor (THRβ) with a new drug called TG68 can help reduce liver fat accumulation and cancer risk in rats with non-alcoholic fatty liver disease (NAFLD).
- Experiments showed that TG68 significantly lowered liver weight, fat, cholesterol, and blood sugar levels while also reversing early signs of liver cancer in the rats.
- Unlike another drug, Resmetirom, which only reduced liver fat, TG68 also demonstrated potential anti-cancer effects, highlighting its promise as a treatment for NAFLD-related liver issues.
Background: Thyroid hormones (THs) inhibit hepatocellular carcinoma (HCC) through different mechanisms. However, whether microRNAs play a role in the antitumorigenic effect of THs remains unknown.
Methods: By next generation sequencing (NGS) we performed a comprehensive comparative miRNomic and transcriptomic analysis of rat hepatic preneoplastic lesions exposed or not to a short-term treatment with triiodothyronine (T3).
Deletion of Lactate Dehydrogenase-A Impairs Oncogene-Induced Mouse Hepatocellular Carcinoma Development.
Cell Mol Gastroenterol Hepatol
August 2022
Background And Aims: Hepatocellular carcinoma (HCC) is a multistep process whereby abnormally proliferating cancer cells undergo extensive metabolic reprogramming. Metabolic alterations in hepatocarcinogenesis depend on the activation of specific oncogenes, thus partially explaining HCC heterogeneity. c-Myc oncogene overexpression, frequently observed in human HCCs, leads to a metabolic rewiring toward a Warburg phenotype and production of lactate, resulting in the acidification of the extracellular space, favoring the emergence of an immune-permissive tumor microenvironment.
View Article and Find Full Text PDFObjectives: Adult hepatocytes are quiescent cells that can be induced to proliferate in response to a reduction in liver mass (liver regeneration) or by agents endowed with mitogenic potency (primary hyperplasia). The latter condition is characterized by a more rapid entry of hepatocytes into the cell cycle, but the mechanisms responsible for the accelerated entry into the S phase are unknown.
Materials And Methods: Next generation sequencing and Illumina microarray were used to profile microRNA and mRNA expression in CD-1 mice livers 1, 3 and 6 h after 2/3 partial hepatectomy (PH) or a single dose of TCPOBOP, a ligand of the constitutive androstane receptor (CAR).