Publications by authors named "A Collotta"
Background: Extracorporeal membrane oxygenation (ECMO) is a life support in newborns with severe respiratory failure. Our main objective was to evaluate the mortality of patients and define positive and negative predictive factors of survival.
Methods: We performed a Strengthening the Reporting of Observational Studies in Epidemiology (STROBE)-conformed retrospective observational study and a systematic review, according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA).
Purpose: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) usually causes a mild disease in children and the most serious consequence is multisystem inflammatory syndrome in children (MIS-C). Currently, there are no data about the protective role of vaccination performed by parents on children regarding the development of MIS-C. The aim of our study is to establish whether parental vaccination is related to MIS-C and the protective value of SARS-CoV-2 vaccination performed by parents against the occurrence of MIS-C in their children.
View Article and Find Full Text PDFAcute Respiratory Tract Infections (ARTIs) in Children after COVID-19-Related Social Distancing: An Epidemiological Study in a Single Center of Southern Italy.
Diagnostics (Basel)
June 2024
Article Synopsis
- In Sicily, viruses like RSV, rhinovirus, and influenza led to increased respiratory infections in children, particularly after lockdowns and during the post-pandemic period.
- A study analyzed respiratory virus data from 204 pediatric patients, revealing that RSV was the most common cause of infections, with rhinovirus and influenza A also being significant contributors.
- The findings suggest a seasonal pattern for these viruses, emphasizing the need for targeted preventive measures, especially for RSV, which was the leading virus during winter months.
Background: The main objective of this study was to evaluate the neurological consequences of delayed pyridoxine administration in patients diagnosed with Pyridoxin Dependent Epilepsies (PDE).
Materials And Methods: We reviewed 29 articles, comprising 52 genetically diagnosed PDE cases, ensuring data homogeneity. Three additional cases were included from the General Pediatric Operative Unit of San Marco Hospital.
Article Synopsis
- - GNAO1 encephalopathy involves severe neurological symptoms like hypotonia, psychomotor retardation, and movement disorders, linked to genetic variations like the E246K mutation in the Gα subunit affecting G protein signaling.
- - Molecular modeling studies were used to explore the impact of the E246K mutation on G protein signal transduction and test the effectiveness of the drug tetrabenazine in addressing these abnormalities.
- - Results showed that tetrabenazine could normalize signal transduction affected by the E246K mutation, suggesting it might be a viable treatment for pediatric patients with this rare form of encephalopathy.