Publications by authors named "A Colbath"
Article Synopsis
- The study investigated the effects of the bisphosphonate clodronate disodium (CLO) on bone health in juvenile sheep over 165 days, analyzing factors like bone turnover, density, and microstructure.
- Forty juvenile sheep were divided into four treatment groups, including a control and three that received CLO at different times, while they were exercised regularly and monitored for physical changes.
- Results showed no significant effects of CLO on the sheep's skeleton, with minor changes in serum bone biomarkers attributed to time and exercise, suggesting the need for further research on low-dose bisphosphonates in active juvenile populations.
Background: Platelet-rich plasma (PRP) and mesenchymal stromal or stem cells (MSCs) have been investigated as treatments for equine tendon and ligament injuries, but little consensus exists on the efficacy of these treatments. The study sought to evaluate the efficacy of PRP and MSC treatments by systematic review and meta-analysis.
Methods: A systematic review was performed using the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis) guidelines.
Neurological diseases and injuries in veterinary patients (horses, dogs, and cats) are complex, and effective treatment options are limited. Neuronal loss, damage to nerve conduction pathways, and inflammation and scarring associated with spinal cord injury pose major challenges in managing many neurological diseases. Furthermore, most of these neuropathologies lack definitive pharmacological treatments, driving interest and research into novel interventions.
View Article and Find Full Text PDFPlatelet-rich plasma (PRP) and other platelet-derived products represent a subset of regenerative medicine and have been researched in the veterinary community for the treatment of osteoarthritis, soft tissue wounds, tendinopathies, periodontitis, and fracture repairs. PRP is simple to produce, relatively affordable, safe, and can be delivered on site, making it an appealing therapeutic agent in veterinary medicine. As an orthobiologic for the treatment of osteoarthritis, it is one of few interventions with clinical study support that possess anabolic potential.
View Article and Find Full Text PDFBackground: Pathological fractures have been reported in equids with pituitary pars intermedia dysfunction (PPID) but their prevalence and pathogenesis is unknown.
Objectives: To compare: (1) bone mineral density (BMD) in weight bearing and nonweight bearing bones in PPID equids and aged and young PPID controls; and (2) biomechanical properties of the fourth lumbar vertebral body in PPID equids and aged PPID equids.
Study Design: Case-control study: five PPID equids and six aged and four young PPID control horses.