Unique effect of aspirin on local 15-oxo-eicosatetraenoic acid synthesis in asthma patients with aspirin hypersensitivity.

Background: Nonsteroidal anti-inflammatory drugs-exacerbated respiratory disease (NSAIDs-ERD) is characterized by altered arachidonic acid (AA) metabolism. Aspirin hypersensitivity is diagnosed using aspirin challenge, while induced sputum is collected to perform cell counts and to identify local biomarkers in induced sputum supernatant (ISS). This study aimed to assess the levels of a newly identified eicosanoid, 15-oxo-eicosatetraenoic acid (15-oxo-ETE), in ISS at baseline and during aspirin-induced bronchospasm in patients with NSAIDs-ERD.

Radiotelemetry reveals the dependence of inland tern breeding and foraging habitats on ADCP-identified sediment aggradation reaches in lowland rivers.

The largest rivers in developed countries have usually been turned into waterways by straightening them and removing large bedforms hampering navigation. For river restoration and their sustainable management it is important to know how large bedforms support biodiversity, whether they could be protected and what potential conflicts in river management they can pose. We have addressed these questions by studying the role of large bedforms in supporting populations of two inland tern species Sternula albifrons and Sterna hirundo.

Sex Differences in Fractional Flow Reserve Utilization.

: The literature review shows that female patients are more frequently underdiagnosed or suffer from delayed diagnosis. Recognition of sex-related differences is crucial for implementing strategies to improve cardiovascular outcomes. We aimed to assess sex-related disparities in the frequency of fractional flow reserve (FFR)-guided procedures in patients who underwent angiography and/or percutaneous coronary intervention (PCI).