Repeated Cytoreduction Combined with Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in Selected Patients Affected by Peritoneal Metastases: Italian PSM Oncoteam Evidence.

The reiteration of surgical cytoreduction (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) in patients affected by recurrent peritoneal metastases is still questioned regarding safety and effectiveness. This study evaluates the safety, efficacy, and associated factors of iterative CRS combined with HIPEC. This multicentric retrospective study collected data from four surgical oncology centers, on iterative HIPEC.

Synthesis of β-cyclodextrin-based nanosponges for remediation of 2,4-D polluted waters.

Two cyclodextrin-based nanosponges (CD-NSs) were synthesized using diamines with 6 and 12 methylene groups, CDHD6 and CDHD12, respectively, and used as adsorbents to remove 2,4-D from aqueous solutions. The physico-chemical characterization of the CD‒NSs demonstrated that, when using the linker with the longest chain length, the nanosponges show a more compact structure and higher thermal stability, probably due to hydrophobic interactions. SEM micrographs showed significant differences between the two nanosponges used.

Removal of sulfanilamide by tailor-made magnetic metal-ceramic nanocomposite adsorbents.

Three tailor-made magnetic metal-ceramic nanocomposites, obtained from zeolite A (ZA1 and ZA2) and a natural clinoptilolite (LB1), have been used as adsorbents to remove sulfanilamide (SA), a sulfonamide antibiotic of common use, from water. A patented process for the synthesis of nanocomposites has been suitably modified to maximize the efficiency of the SA removal, as well as to extend the applicability of the materials. The role played by the main process parameters (kinetic, pH, initial concentration of SA) has been characterized.

Study Protocol: Phase I Dose Escalation Study of Oxaliplatin, Cisplatin and Doxorubicin Applied as PIPAC in Patients with Peritoneal Metastases.

Pressurized Intra-Peritoneal Aerosol Chemotherapy (PIPAC) is a novel laparoscopic intraperitoneal chemotherapy approach offered in selected patients affected by non-resectable peritoneal carcinomatosis. Drugs doses currently established for nebulization are very low: oxaliplatin (OXA) 120 mg/sm, cisplatin (CDDP) 10.5 mg/sm and doxorubicin (DXR) 2.

A Phase I Dose Escalation Study of Oxaliplatin, Cisplatin and Doxorubicin Applied as PIPAC in Patients with Peritoneal Carcinomatosis.

Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) is an innovative laparoscopic intraperitoneal chemotherapy approach with the advantage of a deeper tissue penetration. Thus far, oxaliplatin has been administered at an arbitrary dose of 92 mg/m, cisplatin at 7.5 mg/m and doxorubicin 1.