Pentaenolate activation in the organocatalytic allylic alkylation of indene-2-carbaldehydes.

In this manuscript, the application of pentaenolate intermediates in the allylic alkylation of indene-2-carbaldehydes with Morita-Baylis-Hillman (MBH) carbonates is described. The reaction has been carried out in a highly enantio- and diastereoselective manner due to the use of a chiral tertiary amine as a nucleophilic catalyst. The developed reactivity constitutes the first application of organocatalytic pentaenolate activation in asymmetric synthesis, expanding the arsenal of catalytic methods.

Prolonged QRS duration in patients with heart failure: relation to exercise tolerance, diastolic function and aetiology.

Background: In patients with chronic heart failure (CHF) QRS prolongation is a frequent finding and is related to increased morbidity and mortality. It is not clear if prolonged QRS in CHF of ischaemic origin (CAD) represents the same severity of the syndrome as in non-ischaemic (non-CAD) cardiomyopathy.

Aim: To assess the relationship between QRS duration and BNP levels, diastolic function and peak VO2 in patients with CAD CHF and non-CAD CHF.

[Left ventricular remodelling and rebuilding of the infarcted area. Morphometric evaluation of the relationships between left ventricular mass, myocyte diameter, capillary density and fibrosis].

Unlabelled: The aim of the study was to assess the structural changes in both the infarcted region and free left ventricular (LV) wall that underly post-infarct LV remodeling in the human heart.

Material And Methods: Morphometric evaluation was performed in 31 human hearts, as follows: group I (control)--non-cardiac death (mean age: 52.4 +/- 11.

Short- and long-term mortality in patients with ST-elevation myocardial infarction treated with different therapeutic strategies. Results from WIelkopolska REgional 2002 Registry (WIRE Registry).

Background: Although primary coronary angioplasty seems to be the best treatment in acute myocardial infarction (MI), thrombolytic therapy still remains the most common reperfusion strategy particularly in smaller centers. Nowadays, different regional networks are developed to improve the treatment of patients with MI.

Aim: To analyse the effects of different therapeutic strategies on 30-day and long-term mortality (median time 18.

Mortality in patients with heart failure treated with cardiac resynchronisation therapy. A long-term multi-centre follow-up study.

Background: Benefits of cardiac resynchronisation therapy (CRT) for survival in selected congestive heart failure (CHF) patients have been acknowledged by the 2005 ESC guidelines.

Aim: To analyse mortality in CRT pacing only (CRT-P) patients during at least one-year follow-up.

Methods: This was a prospective, multi-site, at least one-year observational study on mortality and mode of death in patients who received CRT-P due to commonly accepted indications.