Publications by authors named "A Cicenia"
Article Synopsis
- The influenza A(H1N1) pdm09 virus, first identified in 2009, has been studied over a 14-year period (2009-2023) to analyze its genetic changes, particularly focusing on surface proteins hemagglutinin (HA) and neuraminidase (NA) in Italian strains compared to global versions.
- Phylogenetic analyses showed rapid changes and the emergence of new viral variants in the early pandemic, clustered mainly in clade 6B.1, while the 2023 strains displayed limited genetic variation likely due to genetic drift.
- Key sites were identified on both HA and NA proteins that affect the virus's ability to adapt to host immune responses; changes at these sites can serve
Purpose: Despite the absorption of oral thyroxine (T4) occurs in the small bowel, several patients with gastric disorders show an increased need for T4. In vitro evidence suggested that medium pH variations interfere with T4 dissolution. This study was aimed at finding the proof of concept of a direct relationship between the minimal effective dose of T4 and the actual gastric juice pH.
View Article and Find Full Text PDFBackground: It is still a matter of debate if neuromuscular alterations reflect a primary event in diverticular disease (DD).
Aims: This study aimed to assess colonic wall layers from both stenotic and non-stenotic complicated DD, bio-phenotypic alterations, inflammatory and oxidative status.
Methods: A systematic analysis of colonic specimens obtained from stenotic and non-stenotic DD specimens was conducted and compared with controls.
In the past few decades, the increasing socioeconomic burden of acute diverticulitis (AD) has become evident, and with the growth of the population age, this significant economic impact will likely continue to rise. Furthermore, recent evidence showed an increased rate of hospital admissions especially evident among women and younger individuals. The natural history and pathophysiology of this clinical condition is still to be fully defined, and efforts continue to be made in the identification of risk factors and the establishment of relative preventive strategies.
View Article and Find Full Text PDFBackground: Obesity is characterized by a systemic low-grade chronic inflammatory oxidative condition that affects vascular and cardiac smooth muscle relaxation. In human antrum, relaxation is mediated by vasoactive intestinal peptide (VIP) through cAMP and cGMP signaling pathways. A genome-wide association study has demonstrated an association between VIP and obesity.
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