Publications by authors named "A Christopoulos"

Reptiles are unable to generate metabolic heat and regulate body temperature behaviorally depending on environmental conditions. The thermal quality of their habitat is therefore of pivotal importance for their survival. Lizards render themselves as ideal ectothermic models, and their thermal biology has been extensively studied.

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Background: The CO laser is frequently used during microlaryngeal surgery (MLS) for a variety of pathology including laryngeal malignancy and stenosis. Learning how to use the laser safely is part of the curriculum for every otolaryngology resident. However, assessment of laryngoscopy technical skills can be challenging for supervisors, making it difficult to adequately provide feedback to trainees.

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The activation of a G protein-coupled receptor (GPCR) leads to the formation of a ternary complex between agonist, receptor, and G protein that is characterized by high-affinity binding. Allosteric modulators bind to a distinct binding site from the orthosteric agonist and can modulate both the affinity and the efficacy of orthosteric agonists. The influence allosteric modulators have on the high-affinity active state of the GPCR-G protein ternary complex is unknown due to limitations on attempting to characterize this interaction in recombinant whole cell or membrane-based assays.

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Article Synopsis
  • This study examined if esophageal speech (ES) as a vocal rehabilitation method after total laryngectomy can improve patients' quality of life (QoL) and vocal abilities based on personal reports.
  • Nine studies were reviewed using various data sources, with a focus on standardized questionnaires and audio analyses, and biases checked using CASP tools.
  • While some patients reported improvements in QoL and vocal functionality, others faced challenges with learning ES and phonetic performance, leading to mixed results; overall, the technique's effectiveness may vary based on individual circumstances.
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