Novel mTORC2/HSPB4 Interaction: Role and Regulation of HSPB4 T148 Phosphorylation.

HSPB4 and HSPB5 (α-crystallins) have shown increasing promise as neuroprotective agents, demonstrating several anti-apoptotic and protective roles in disorders such as multiple sclerosis and diabetic retinopathy. HSPs are highly regulated by post-translational modification, including deamidation, glycosylation, and phosphorylation. Among them, T148 phosphorylation has been shown to regulate the structural and functional characteristics of HSPB4 and underlie, in part, its neuroprotective capacity.

A coaxial solid state nonlinear pulse forming line with an exponentially tapered ferrite composite core.

The need to optimize size, weight, and power of high-power microwave (HPM) systems has motivated the development of solid-state HPM sources, such as nonlinear transmission lines (NLTLs), which utilize gyromagnetic precession or dispersion to generate RF. One recent development implemented the NLTL as a pulse forming line (PFL) to form a nonlinear pulse forming line (NPFL) system that substantially reduced the system's size by eliminating the need for a separate PFL; however, matching standard loads can be challenging. This paper describes the development of a tapered NPFL using an exponentially tapered composite based ferrite core containing 60% nickel zinc ferrite (by volume) encased in polydimethylsiloxane (PDMS) and encapsulated in a 5% barium strontium titanate shell.

Risk Factors for Consensual and Coercive Sexual Hookup Behaviors among College Men: A Daily Diary Study.

Objective: Hookup behaviors (HUBs; i.e., sexual activity outside an exclusive relationship with no mutual expectation of romantic commitment) are prevalent on college campuses and are linked with alcohol use and sexual assault.

Polychlorinated biphenyl (PCB) concentrations and breakpoint trends across the waters of the Great Lakes by isotope-dilution high-resolution mass spectroscopy.

Water samples were collected during each of the 2012-2019 Cooperative Science and Monitoring Initiative (CSMI) cruises aboard the U.S. EPA R/V Lake Guardian as part of the Great Lakes Fish Monitoring and Surveillance Program (GLFMSP) lower food web contaminant assessment.