Publications by authors named "A Christoforou"

Canadians consume excessive amounts of sodium, a leading risk factor for cardiovascular disease. In 2012, Health Canada released guidance outlining voluntary sodium reduction benchmarks for pre-packaged foods to be met by manufacturers by 2016. Using the University of Toronto's Food Label Information Program(FLIP), the aim of this study was to evaluate changes in average sodium content of Canadian pre-packaged foods from 2013 to 2017 and manufacturers' progress in meeting final phase III sodium reduction benchmark targets.

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Background: Functional neurological disorder (FND) is a common and disabling neuropsychiatric condition, which disproportionally affects women compared with men. While the etiopathogenesis of this disorder remains elusive, immune dysregulation is emerging as one potential mechanism. To begin to understand the role of immune dysfunctions in FND, we assessed the prevalence of several common autoimmune diseases (ADs) in a large cohort of patients with FND and examined the influence of psychiatric comorbidities and biological sex.

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Objective/background: Unmet needs in perinatal mental healthcare are an important public health issue particularly in the context of a stressful life event such as the COVID-19 pandemic but data on the extent of this problem are needed.

Aim: The aim of this study is to determine the (1) proportion of women with clinically significant symptoms of perinatal depression, anxiety or comorbid symptoms of depression and anxiety, receiving mental healthcare overall and by country and (2) factors associated with receiving mental healthcare.

Method: Women in the perinatal period (pregnancy or up to 6 months postpartum) participating in the Riseup-PPD-COVID-19 cross-sectional study, reported on sociodemographic, social support health-related factors, and COVID-19 related factors, and on symptoms of depression (Edinburgh Postnatal Depression Scale [EPDS]) and anxiety (Generalised Anxiety Disorder [GAD-7]) using self-report questionnaires.

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Article Synopsis
  • Immunomodulatory drugs (IMiDs) are important treatments for myeloma and myelodysplastic syndrome, but they increase the risk of thrombosis, which can lead to serious complications.
  • This study explored how IMiDs affect thrombosis by examining cereblon substrates in human megakaryocytes, finding that thrombospondin-1 (THBS-1) accumulates abnormally when IMiDs interfere with its degradation.
  • The results indicate that the accumulation of THBS-1, caused by disrupted cereblon interaction due to IMiDs, may contribute to the increased risk of thromboembolism in patients undergoing IMiD treatment.
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Introduction: Paternal peripartum depression (P-PPD) is a serious and understudied public health problem associated with impaired family functioning and child development. The lack of recognition of P-PPD may result in limited access to both information and professional help.

Objective: The aim of the study was to review studies on paternal peripartum depression and to identify issues and questions where future research and theory formation are needed.

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