Detection of clinically relevant variants in the gene below 10% allelic frequency: A multicenter study by ERIC, the European Research Initiative on CLL.

In chronic lymphocytic leukemia, the reliability of next-generation sequencing (NGS) to detect variants ≤10% allelic frequency (low-VAF) is debated. We tested the ability to detect 23 such variants in 41 different laboratories using their NGS method of choice. The sensitivity was 85.

Earlier diagnosis of small intestine neuroendocrine tumours (SI-NETs) through transformation of the South Wales NET service.

Small intestine neuroendocrine tumours (SI-NETs) are often diagnosed late with a UK median of 3 years and high misdiagnosis rates. Previous studies, largely based on patient surveys, offer little data on improving diagnosis. In 2017, the South Wales NET service underwent a nationally commissioned, systematic transformation, aiming to improve diagnosis through the development of a gastroenterology and surgical referral network, and education of these specialities.

Energy and vulnerability: Exploring the energy poverty-risky sexual behavior nexus among young women in Ghana.

While recent policy agendas have extensively addressed both energy poverty and risky sexual behavior separately, little research has explored their intersection. This pioneering study investigates the relationship between energy deprivation and risky sexual behavior in female youth. Utilizing data from the Demographic and Health Survey in Ghana and employing robust methodologies, including the Lewbel two-stage regression and alternative energy deprivation thresholds, our findings reveal an 8.

Sibling gender dynamics and childhood stunting in Ghana.

Background: Stunting remains a public health concern in sub-Saharan Africa. Despite the evolving awareness of the effect of family composition on child health outcomes, the influence of sibling gender on stunting has seldom been consistent. The current study investigated the association between sibling composition and stunting among children under five years in Ghana.

The food dye Tartrazine disrupts vascular formation both in zebrafish larvae and in human primary endothelial cells.

Tartrazine (E102) is a controversial coloring agent whose potential impacts on human health are not fully understood. Our study reveals the vascular disrupting effects of tartrazine (TTZ) on developing zebrafish embryos in vivo and on human umbilical vein endothelial cells in vitro. The dye was shown to cause dose-dependent hemorrhages in zebrafish embryos.