Publications by authors named "A Choy"
Melanomas show a wide spectrum of clinical, morphological, immunohistochemical, and molecular features, which can impact treatment and prognosis. Dedifferentiated and transdifferentiated melanomas (DTM) are defined as melanomas which have lost conventional melanocytic morphologic and immunohistochemical features, showing sarcomatous morphology and/or immunohistochemical staining of other cell lineages, and as such, can be mistaken for other entities such as collision tumors and undifferentiated spindle cell tumors. In this series, we highlight the utility of preferentially expressed antigen in melanomas (PRAME) in diagnosing undifferentiated/dedifferentiated melanomas.
View Article and Find Full Text PDFStricture formation is a common complication after restorative proctocolectomy and Kock pouch surgery. Endoluminal functional lumen imaging probe (EndoFLIP) is a balloon catheter device that uses impedance planimetry to provide luminal pressure and dimension measurements. This case describes the first use of EndoFLIP to quantify the distensibility and diameter of a Kock pouch stricture before and after endoscopic balloon dilation and needle knife stricturotomy.
View Article and Find Full Text PDFArticle Synopsis
- Vancouver Coastal Health (VCH) Authority in British Columbia serves both urban and rural areas, making it a unique case for studying care services for asthma and chronic obstructive pulmonary disease (COPD).
- An environmental scan revealed that specialized care services for asthma and COPD are limited in urban areas and largely unavailable in rural areas, with spirometry services falling significantly short of needs in both regions.
- None of the 16 identified quality improvement (QI) initiatives for asthma and COPD were conducted in rural VCH healthcare sites, indicating a significant gap in care accessibility and a need for targeted future QI initiatives in those communities.
Introduction: Human metabolomics has made significant strides in understanding metabolic changes and their implications for human health, with promising applications in diagnostics and treatment, particularly regarding the gut microbiome. However, progress is hampered by issues with data comparability and reproducibility across studies, limiting the translation of these discoveries into practical applications.
Objectives: This study aims to evaluate the fit-for-purpose of a suite of human stool samples as potential candidate reference materials (RMs) and assess the state of the field regarding harmonizing gut metabolomics measurements.