CD3+ T-cell: CD14+ monocyte complexes are dynamic and increased with HIV and glucose intolerance.

Persistent systemic inflammation is associated with an elevated risk of cardiometabolic diseases. However, the characteristics of the innate and adaptive immune systems in individuals who develop these conditions remain poorly defined. Doublets, or cell-cell complexes, are routinely eliminated from flow cytometric and other immune phenotyping analyses, which limits our understanding of their relationship to disease states.

Burden of Musculoskeletal (MSK) Pain and Arthritis in India: A Community Oriented Program for Control of Rheumatic Diseases (COPCORD-Bone and Joint Decade (BJD)) India Project.

Background: Several countries have participated in WHO COPCORD. The Global Disease Burden program (GBD) reports selected MSK disorders. We used a COPCORD India protocol to estimate the national burden of MSK disorders.

Single-cell immunopathology of recurrent acute generalized exanthematous pustulosis associated with vancomycin.

Background: Acute generalized exanthematous pustulosis (AGEP) is a severe cutaneous adverse reaction to medication that presents within 72 hours of exposure with erythematous papules and plaques with overlying pustules. The immunopathogenesis and predisposing factors of AGEP are not well characterized.

Objective: To better understand the genetic risk factors and single-cell immunopathogenesis of AGEP, we longitudinally characterized a patient with recurrent AGEP after an initial episode triggered by vancomycin.