Neuropathological Examination of Mice Chronically Exposed to Secondhand Smoke.

Introduction: Around 21.6-35% of military personnel are smokers, while 12.26% of them have been regularly exposed to second-hand smoke (SHS).

Implementation of Just Culture Policy in Nursing Programs to Support Quality Safety Competency.

Background: Despite the shift to a just culture (JC) in health care systems more than a decade ago, many nursing programs continue to lack a JC environment, which may result in students entering the workforce without adequate preparation. This study evaluated prelicensure nursing students' perceptions of JC at baseline and 4 months after policy implementation.

Method: The JC Assessment Tool for Nursing Education (JCAT-NE) was used to measure nursing students' perceptions of JC.

Landscape of functional interactions of human processive ribonucleases revealed by high-throughput siRNA screenings.

Processive exoribonucleases are executors of RNA decay. In humans, their physical but not functional interactions were thoughtfully investigated. Here we have screened cells deficient in DIS3, XRN2, EXOSC10, DIS3L, and DIS3L2 with a custom siRNA library and determined their genetic interactions (GIs) with diverse pathways of RNA metabolism.

Effects of Chronic Secondhand Smoke (SHS) Exposure on Cognitive Performance and Metabolic Pathways in the Hippocampus of Wild-Type and Human Tau Mice.

Background: Exposure to secondhand smoke (SHS) is a risk factor for developing sporadic forms of sporadic dementia. A human tau (htau) mouse model is available that exhibits age-dependent tau dysregulation, neurofibrillary tangles, neuronal loss, neuroinflammation, and oxidative stress starting at an early age (3-4 months) and in which tau dysregulation and neuronal loss correlate with synaptic dysfunction and cognitive decline.

Objective: The goal of this study was to assess the effects of chronic SHS exposure (10 months' exposure to ) on behavioral and cognitive function, metabolism, and neuropathology in mice.