Publications by authors named "A Chizuka"
Since the long-term safety profile of tyrosine kinase inhibitors (TKI) in chronic myeloid leukemia (CML) therapy has not been well characterized, we investigated renal impairment in 50 CML patients treated with TKI in our institute. During the median follow up period of 63 months, 29% of patients developed chronic kidney disease (CKD). Although the glomerular filtration rate (GFR) gradually declined, it dropped most markedly in the first 2 years after starting TKI.
View Article and Find Full Text PDFThe safety and efficacy of treatment with liposomal amphotericin B (L-AMB) in elderly patients has not been clarified, especially in Japanese patients. Therefore, we retrospectively analyzed 33 elderly patients with hematological diseases of at least 65 years old who received L-AMB between 2009 and 2012. Their clinical outcomes were compared to those of 21 patients who were younger than 65 years.
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- A 37-year-old pregnant woman with a history of paroxysmal nocturnal hemoglobinuria (PNH) was treated with eculizumab, which successfully managed her condition without hemolytic attacks since starting the treatment at age 35.
- During her pregnancy, she continued eculizumab with no complications or exacerbation of hemolysis, leading to a successful Caesarean delivery of a healthy girl at 37 weeks and 3 days.
- Post-delivery, she received anticoagulant therapy and experienced mild hemolysis without thrombotic symptoms; both eculizumab and signs of hemolysis blockage were detected in the cord blood and breast milk.
A 72-year-old man visited our hospital in July 2009 with a major complaint of lightheadedness. Based on bone marrow aspiration, myelodysplastic syndrome (MDS), refractory anemia with excessive blast-2 was diagnosed. Complete remission (CR) was achieved after low-dose cytarabine and aclarubicin therapy.
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