Publications by authors named "A Chirindel"
Background: Adoptive cell therapy (ACT) with tumor-infiltrating lymphocytes (TIL) is a personalized immunotherapy. The efficacy of TIL-ACT has been demonstrated prospectively in patients with advanced melanoma but is not limited to melanoma patients. Many patients are refractory to TIL-ACT, however, or their cancer becomes resistant.
View Article and Find Full Text PDFPurpose: To optimize and assess an abbreviated dual time-point 18-Fluor-Deoxyglucose (FDG)-Positron Emission Tomography (PET)/Magnetic Resonance Imaging (MRI) protocol for predicting patient outcomes in pancreatic cancer.
Methods: 70 patients (47 pancreatic cancer, 23 chronic pancreatitis) underwent hybrid PET/MRI with dual time-point PET/CT at 60 and 84 minutes post-injection. Metabolic indices (MI) were calculated from Standardized Uptake Value (SUV) changes (SUVmin, SUVmean and SUVmax).
Article Synopsis
- The current method for detecting active Brown Adipose Tissue (BAT) using [F]-FDG PET/CT imaging is expensive and exposes patients to radiation, making it impractical for large studies.
- Previous research indicates a correlation between BAT's Hounsfield Unit (HU) in CT scans and [F]-FDG uptake, which can help develop computational methods to predict BAT activity.
- This study introduces convolutional neural networks (CNNs) to predict [F]-FDG uptake from unenhanced CT scans, achieving better accuracy and distinguishing subjects with active BAT more effectively than traditional methods.