Publications by authors named "A Chateau"
Background: Epidermolysis bullosa (EB) is a rare genodermatosis that results in extreme skin fragility, for which there is no cure and may be fatal. The quality of life of patients affected may be greatly impacted.
Aim: This study aims to understand the lived experiences of patients with EB.
Article Synopsis
- Leprosy, despite having been eliminated in South Africa since 1926, still sees new cases, highlighting challenges in patient education, adherence, and healthcare training.
- A retrospective study from 2002 to 2022 analyzed data from 194 leprosy patients in KwaZulu-Natal, revealing a majority were middle-aged males, predominantly black South Africans, most of whom were unemployed and 15% were HIV positive.
- Common symptoms included respiratory issues, hair loss, and nerve pain, with many patients not completing the multidrug therapy; 33.5% experienced treatment reactions, and one-fifth suffered debilitating neurological complications.
Background: Epidermolysis bullosa (EB) is a rare, incurable genodermatosis that presents with blistering and skin fragility. Complications can be localised or generalised, limited to the skin or have systemic effects resulting in death. Caring for a child with this painful condition can have a profound effect on the quality of life of parents and the family.
View Article and Find Full Text PDFPurpose: The tumor microenvironment (TME) is composed of various stromal components, including immune cells such as tumor-associated macrophages (TAMs), which play a crucial role in cancer initiation and progression. TAMs can exhibit either a tumor-suppressive M1 or a tumor-promoting M2 phenotype. First, we aimed to develop a 3D human heterotypic model consisting of head and neck squamous cell carcinoma (HNSCC) cells and different subtypes of macrophages to replicate the interactions between immune cells and cancer cells.
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