Publications by authors named "A Chamorro-Jorganes"
Article Synopsis
- The study investigates how bicuspid aortic valve (BAV) leads to dilation of the ascending aorta (AAo) and seeks to understand the molecular and structural changes involved in this condition.
- Researchers analyzed aortic tissue from BAV patients with aortopathy, focusing on differences between dilated and non-dilated segments, specifically looking at microRNAs, protein content, and elastic fiber degeneration.
- The findings revealed five differentially expressed microRNAs linked to dysregulated genes involved in key signaling pathways, alongside structural changes such as reduced elastic fibers in dilated aortic segments with increased wall shear stress.
N6-methyladenosine (m6A) is the most abundant and well-studied internal modification of messenger RNAs among the various RNA modifications in eukaryotic cells. Moreover, it is increasingly recognized to regulate non-coding RNAs. The dynamic and reversible nature of m6A is ensured by the precise and coordinated activity of specific proteins able to insert ("write"), bind ("read") or remove ("erase") the m6A modification from coding and non-coding RNA molecules.
View Article and Find Full Text PDFMicroRNAs (miRNAs) regulate gene expression by post-transcriptional inhibition of target genes. Proangiogenic small extracellular vesicles (sEVs; popularly identified with the name "exosomes") with a composite cargo of miRNAs are secreted by cultured stem cells and present in human biological fluids. Lipid nanoparticles (LNPs) represent an advanced platform for clinically approved delivery of RNA therapeutics.
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