Publications by authors named "A Chalasani"
This study evaluated the paracrine signaling between breast carcinoma-associated fibroblasts (CAFs) and breast cancer (BCa) cells. Resolving cell-cell communication in the BCa tumor microenvironment (TME) will aid the development of new therapeutics. Here, we utilized our patented TAME (tissue architecture and microenvironment engineering) 3D culture microphysiological system, which is a suitable pathomimetic avatar for the study of the BCa TME.
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- Acquired epilepsies begin after a brain injury, leading to the gradual development of seizures, but the processes behind this progression (epileptogenesis) are not fully understood; microRNAs like miR-324-5p have been linked to regulating these processes.
- In a study with mice, researchers tested the effects of inhibiting miR-324-5p during the epileptogenesis phase by using a specific model (IHpKa) and monitoring through EEG for 28 days.
- The findings showed that inhibiting miR-324-5p did not prevent the onset or severity of seizures but did affect certain EEG activity patterns, suggesting that timing of treatment is crucial and that miR-324-5
Gastrointestinal: A discovery hard to swallow: an unusual case of esophageal obstruction.
J Gastroenterol Hepatol
February 2024
Purpose: Rotational thromboelastometry (ROTEM®) allows guided blood product resuscitation to correct trauma-induced coagulopathy in bleeding trauma patients. FIBTEM amplitude at 10 min (A10) has been widely used to identify hypofibrinogenaemia; locally a threshold of < 11 mm has guided fibrinogen replacement. Amplitude at 5 min (A5) carries an inherent time advantage.
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