Publications by authors named "A Chaix"
Article Synopsis
- - A survey of aging researchers revealed significant disagreement on key questions about aging, such as its definition, causes, onset, and rejuvenation, indicating a lack of consensus in the field.
- - Researchers have varying interpretations of what constitutes "aging," leading to different experimental approaches and priorities, which complicates the understanding and study of the aging process.
- - The findings highlight the necessity for clearer definitions and targeted goals within aging research, as well as strategies to address ongoing disagreements, in hopes of advancing the field.
Objective: Glucagon-like peptide 1 receptor agonists (e.g. semaglutide) potently induce weight loss and thereby reducing obesity-related complications.
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- PFAS, harmful substances in water, necessitate urgent remediation advancements, leading to the creation of a specialized 3D printed hydrogel designed to capture these contaminants effectively.* -
- The hydrogel is constructed from a specific combination of materials (DMU-Δ and PDM) using 3D printing techniques, resulting in various porous structures that exhibit impressive uptake capacities and rapid removal rates for PFAS.* -
- Tests reveal that one variant of the hydrogel can remove about 91% of PFAS from water in just 5 hours, and its efficiency is enhanced by adding positive charges, making these hydrogels a safe and promising solution for addressing PFAS pollution.*
Background And Aims: HCC incidence is increasing worldwide due to the obesity epidemic, which drives metabolic dysfunction-associated steatohepatitis (MASH) that can lead to HCC. However, the molecular pathways driving MASH-HCC are poorly understood. We have previously reported that male mice with haploinsufficiency of hypoxia-associated factor (HAF) ( SART1+/ - ) spontaneously develop MASH-HCC.
View Article and Find Full Text PDFTime-Restricted Feeding Reduces Atherosclerosis in LDLR KO Mice but Not in ApoE Knockout Mice.
Arterioscler Thromb Vasc Biol
September 2024
Article Synopsis
- Dyslipidemia, a risk factor for cardiovascular disease, can be mitigated by time-restricted feeding (TRF), which limits food intake to a 12-hour window, resulting in reduced weight gain and cholesterol levels in preclinical mouse models.
- In studies involving mice with LDLR mutations, TRF significantly decreased hypercholesterolemia and atherosclerosis by promoting lipid metabolism and excretion, demonstrating potential benefits for heart health.
- The findings suggest that TRF could serve as an effective lifestyle intervention for reducing cardiovascular risks, particularly in individuals with LDLR-related conditions, though it may not be effective for those lacking the ApoE protein.