Publications by authors named "A Ceschi"
Aims Of The Study: Physicians frequently prescribe antipsychotics off-label to treat, among others, insomnia and anxiety. The Swiss "smarter medicine - Choosing Wisely" campaign has tried to raise awareness about the risks and to limit benzodiazepine and Z-drug prescriptions. In the Italian-speaking part of Switzerland, our network of public hospitals joined the campaign with the aim of avoiding unnecessary benzodiazepine and Z-drug treatments, with prescription monitoring, benchmarking and educational contributions.
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- The study explores late-onset immune-related adverse events (irAEs) from immune checkpoint inhibitors (ICIs), emphasizing the limited evidence available to date.
- It analyzes data from 6006 individual case safety reports (ICSRs) collected in VigiBase, identifying the prevalence and types of late-onset irAEs, finding thyroiditis and pneumonitis to be among the most common.
- The results indicate a strong association between late-onset irAEs and factors like ICI combination therapy, multiple irAEs, cutaneous irAEs, and the specific use of ICIs in melanoma patients.
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- This study evaluates the clinical features and outcomes of acute cannabis toxicity versus acute synthetic cannabinoid receptor agonist toxicity in European emergency departments from 2013-2020.
- Using data from the European Drug Emergencies Network Plus, researchers analyzed 2,657 cases of cannabis exposure and 503 cases of synthetic cannabinoid exposure to compare their effects.
- The findings indicate that synthetic cannabinoid exposures are linked to more severe neuropsychiatric symptoms, while cannabis exposures are associated with cardiovascular issues.
Safety data on the use of monoclonal antibodies inhibiting proprotein convertase subtilisin/kexin type 9 in pregnancy are scarce. This study queried VigiBase®, the World Health Organization global pharmacovigilance database, to search for signals of disproportionate reporting for pregnancy outcomes with alirocumab and evolocumab. As of November 22, 2023, there were 45 safety reports of exposure to evolocumab (N = 31) and alirocumab (N = 14) in pregnancy.
View Article and Find Full Text PDFThis study investigates how remote e-working characteristics are related to employees' well-being in Italy. We conducted a longitudinal study with two time points and a 1-month time lag, involving a final sample of 223 employees. Controlling for the auto-regressive effects of all the outcomes, our results revealed that experiencing work-life balance during e-working was negatively associated with emotional exhaustion and social isolation, while it was positively related to career progression.
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