Publications by authors named "A Ceri"
Liquid biopsy has an underexplored diagnostic potential in colorectal cancer (CRC). Sufficient quantity and quality of its elements (circulating cell-free DNA (ccfDNA), exosomes and exosomal RNA) are essential for accurate results. The present study aims to establish the optimal protocol for handling liquid biopsy samples.
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- This study explored the potential of specific microRNAs (miR-19a-3p, miR-92a-3p, miR-193a-3p, and miR-210-3p) as biomarkers for colorectal cancer (CRC) and compared them to existing markers like carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA 19-9).
- Researchers analyzed tissue samples from 52 CRC and 76 pre-CRC patients, finding that only miR-193a-3p had a significant difference in expression when comparing pre-CRC to CRC and when analyzing CRC tissues vs. exosomes.
- The combination of CEA and miR-193
Background: We aimed to examine inherited thrombophilia frequencies by extending genetic profile to previously rarely or not investigated polymorphisms in children with ischemic pediatric stroke (IPS) and their parents.
Methods: The study included 33 children: 23 with perinatal arterial ischemic stroke (PAIS), eight with childhood arterial ischemic stroke (CAIS), and two with sinovenous thrombosis and their parents (33 mother-child, 12 father-child, and 12 mother-father-child pairs). Genotyping of FV-Leiden, FV-H1299R, FII-G20210A, β-fibrinogen-455G>A, FXIII-A-Val34Leu, PAI-1(4G/5G), HPA-1, MTHFR-C677T, MTHFR-A1298C, ACE(I/D), and APOE(ε2-4) was performed using CVD Strip assay (ViennaLab, Austria).
Colorectal cancer (CRC) is the third most common cancer worldwide. The high mortality from CRC is mainly related to metastasis affecting distant organs and their function. Dissemination of tumor cells from the primary tumor and hematogeneous spread are considered crucial in the formation of tumor metastases.
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