Publications by authors named "A Cefle"
Background: Hematological markers such as the neutrophil-lymphocyte ratio (NLR), monocyte-lymphocyte ratio (MLR), and platelet-lymphocyte ratio (PLR) are reliable indicators of inflammation. This study aims to investigate the potential role of these markers in assessing disease activity and treatment response in biologic-naive Ankylosing Spondylitis (AS) patients following the initiation of biological agents.
Materials And Methods: We designed this study as a retrospective cohort study with data obtained from a single center.
Article Synopsis
- - The study focuses on improving transitional care for adolescents with juvenile idiopathic arthritis (JIA) as they move to adult healthcare systems, suggesting the need for tailored programs in each country.
- - A Delphi study involving adolescents, parents, and clinicians was conducted to gather expert opinions and identify key components of transitional care, with significant participation in the initial surveys.
- - While a consensus was reached on essential transitional care issues for JIA patients, further agreement is needed on practical applications of a final checklist to enhance care in Turkey.
CT-P13 is a biosimilar version of infliximab, a monoclonal antibody. In individuals with ankylosing spondylitis (AS), CT-P13 has been shown to be effective and to have a well-tolerated safety profile. The aim of this study was to evaluate the long-term drug persistence, safety, and efficacy of infliximab biosimilar CT-P13 in patients with AS undergoing first-line (1st-line) and later (≥2nd-line) treatment in clinical practice.
View Article and Find Full Text PDFClinical course of pediatric-onset Behçet's Disease in young adulthood.
Rheumatology (Oxford)
November 2024
Article Synopsis
- The study investigates the progression of Behçet's disease when it starts in childhood and how it affects patients in adulthood.
- Out of 112 pediatric patients, 93 were analyzed, revealing that around 52.5% had major organ involvement, primarily affecting the eyes, with some showing new complications as they transitioned into adulthood.
- The findings highlight the importance of continued monitoring for these patients, as nearly one-third experienced new symptoms or relapses post-childhood, underscoring the need for regular follow-ups to mitigate potential long-term damage.
Objective: To evaluate the development of anti-drug antibodies (ADAb) against tumor necrosis factor inhibitors (TNFi) therapy during a 2-year period and search the factors linked to patients with axial spondyloarthritis (axSpA).
Methods: Biologic-naive patients with axSpA were included in this observational study. Serum drug levels and ADAb were measured at weeks 12, 24, 52, and 104 of treatment by enzyme-linked immunosorbent assay (ELISA).