Publications by authors named "A Cavada Laza"
Article Synopsis
- Research highlights the significant role of immune processes in the development of Alzheimer's disease, which is the leading cause of dementia.
- Various studies indicate that both innate and adaptive immune responses contribute to the disease's pathology and are influenced by genetics and lifestyle factors.
- New therapeutic approaches targeting neuroinflammation are being explored in clinical settings, offering potential treatment options for Alzheimer's patients.
A disposable electrochemical PCR-free biosensor for the selective detection of a fragment encoding the protein Sin a 1, a 2S albumin considered a diagnostic marker for sensitization to mustard, is reported. The methodology is based on the formation of DNA/RNA heterohybrids by sandwich hybridization of a specific fragment of the Sin a 1 allergen coding sequence with appropriately designed RNA probes. Labeling with commercial antibodies specific to the heteroduplexes and secondary antibodies conjugated with horseradish peroxidase (HRP) was carried out onto the surface of magnetic beads (MBs).
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- - COVID-19 has led to over 3.5 million deaths and more than 160 million infections, with many individuals experiencing neurological issues, including loss of smell, seizures, and strokes, which can lead to long-term cognitive and neuropsychiatric problems regardless of the severity of respiratory symptoms.
- - The article explores potential links between COVID-19 and neurological symptoms, particularly focusing on Alzheimer's disease and related dementias, while examining factors like inflammation and viral mechanisms that may cause such issues.
- - A global research effort, the CNS SC2 consortium, is underway to standardize methods for studying the long-term effects of COVID-19 on brain health, with data collection occurring across multiple countries to improve overall understanding.
APOE ɛ4, the most significant genetic risk factor for Alzheimer disease (AD), may mask effects of other loci. We re-analyzed genome-wide association study (GWAS) data from the International Genomics of Alzheimer's Project (IGAP) Consortium in APOE ɛ4+ (10 352 cases and 9207 controls) and APOE ɛ4- (7184 cases and 26 968 controls) subgroups as well as in the total sample testing for interaction between a single-nucleotide polymorphism (SNP) and APOE ɛ4 status. Suggestive associations (P<1 × 10(-4)) in stage 1 were evaluated in an independent sample (stage 2) containing 4203 subjects (APOE ɛ4+: 1250 cases and 536 controls; APOE ɛ4-: 718 cases and 1699 controls).
View Article and Find Full Text PDFA series of intercalated and exfoliated nanocomposites montmorillonite-ulvan was prepared. Ulvan, extracted from the green algae, is a water-soluble polysaccharide biopolymer. Depending on the drying process, air or freeze drying, ulvan were inserted in the interlayer space or adsorbed on the both sides of inorganic layers.
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