Publications by authors named "A Catalani"

Article Synopsis
  • Botrytis cinerea (Bc) is a fungus causing gray mold in wine grapes that can also lead to noble rot, crucial for producing sweet and high-quality wines like Amarone.
  • This study focused on the early detection of noble rot on Trebbiano grapes using both destructive and non-destructive methods, aiming to monitor the fungus's growth shortly after infection.
  • Results confirmed that Bc infection significantly alters grape composition, and non-destructive technologies successfully identified early stages of the fungus's development, providing insights for better grape management in winemaking.
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Arsenite, a well-established human carcinogen and toxic compound, promotes the formation of mitochondrial superoxide (mitoO) via a Ca-dependent mechanism, in which an initial stimulation of the inositol 1, 4, 5-trisphosphate receptor (IPR) is followed by the activation of the ryanodine receptor (RyR), critical for providing Ca to the mitochondria. We now report that, under the same conditions, arsenite triggers endoplasmic reticulum (ER) stress and a threefold increase in ER oxidoreductin 1α (ERO1 α) levels in proliferating U937 cells. EN460, an inhibitor of ERO1 α, recapitulated all the effects associated with RyR inhibition or downregulation, including prevention of RyR-induced Ca accumulation in mitochondria and the resulting O formation.

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Arsenite induces many critical effects associated with the formation of reactive oxygen species (ROS) through different mechanisms. We focused on Ca-dependent mitochondrial superoxide (mitoO) formation and addressed questions on the effects of low concentrations of arsenite on the mobilization of the cation from the endoplasmic reticulum and the resulting mitochondrial accumulation. Using various differentiated and undifferentiated cell types uniquely expressing the inositol-1, 4, 5-triphosphate receptor (IPR), or both the IPR and the ryanodine receptor (RyR), we determined that expression of this second Ca channel is an absolute requirement for mitoO formation and for the ensuing mitochondrial dysfunction and downstream apoptosis.

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Objective: Countries have major differences in the acceptance of face mask use for the prevention of COVID-19. This work aims at studying the information online in different countries in terms of information quality and content.

Design: Content analysis.

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The fact that Internet companies may record our personal data and track our online behavior for commercial or political purpose has emphasized aspects related to online privacy. This has also led to the development of search engines that promise no tracking and privacy. Search engines also have a major role in spreading low-quality health information such as that of anti-vaccine websites.

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