Unveiling the interplay between soluble guanylate cyclase activation and redox signalling in stroke pathophysiology and treatment.

Soluble guanylate cyclase (sGC) stands as a pivotal regulatory element in intracellular signalling pathways, mediating the formation of cyclic guanosine monophosphate (cGMP) and impacting diverse physiological processes across tissues. Increased formation of reactive oxygen species (ROS) is widely recognized to modulate cGMP signalling. Indeed, oxidatively damaged, and therefore inactive sGC, contributes to poor vascular reactivity and more severe neurological damage upon stroke.

Implementation of Principal Component Analysis (PCA)/Singular Value Decomposition (SVD) and Neural Networks in Constructing a Reduced-Order Model for Virtual Sensing of Mechanical Stress.

This study presents the design and validation of a numerical method based on an AI-driven ROM framework for implementing stress virtual sensing. By leveraging Reduced-Order Models (ROMs), the research aims to develop a virtual stress transducer capable of the real-time monitoring of mechanical stresses in mechanical components previously analyzed with high-resolution FEM simulations under a wide range of multiple load scenarios. The ROM is constructed through neural networks trained on Finite Element Method (FEM) outputs from multiple scenarios, resulting in a simplified yet highly accurate model that can be easily implemented digitally.

Engineering biology and automation-Replicability as a design principle.

Applications in engineering biology increasingly share the need to run operations on very large numbers of biological samples. This is a direct consequence of the application of good engineering practices, the limited predictive power of current computational models and the desire to investigate very large design spaces in order to solve the hard, important problems the discipline promises to solve. Automation has been proposed as a key component for running large numbers of operations on biological samples.

Multiple Uses of Wild Edible Trees by a Nahua-Origin Community in Western Mexico.

Wild edible trees (WETs) play an important role in the diet of many rural communities. Therefore, research on their use and management is important to support both food sovereignty and local conservation of biocultural resources. We evaluated the different uses of WETs by the community of Zacualpan, Colima, in western Mexico, through 32 semi-structured interviews registering the species richness, plant parts consumed, and non-food uses.