Publications by authors named "A Carver"
Maintaining genome integrity is an essential and challenging process. RAD51 recombinase, the central player of several crucial processes in repairing DNA and protecting genome integrity, forms filaments on DNA, which are tightly regulated. One of these RAD51 regulators is FIGNL1, that prevents persistent RAD51 foci without or after DNA damage and genotoxic chromatin association in cells.
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- Despite national efforts to highlight the importance of capnography for confirming tracheal intubation, deaths from unrecognized esophageal intubation persist, prompting the adoption of a two-person verbal check during the intubation process.
- In a study across two hospitals, one implemented a one-step check and the other a two-step check, collecting feedback from anaesthetists and assistants via anonymous questionnaires throughout the process.
- The majority of participants felt that the two-person checks enhanced communication and teamwork, with high support for continued use; 82% of intubators and 94% of assistants intended to use this method for future intubations.
Article Synopsis
- Radiotherapy treatment planning is shifting towards more automation, similar to the changes seen in the aviation industry, raising concerns about human roles and risks within these automated systems.
- A working group at the ESTRO Physics Workshop 2023 suggested a framework based on aviation insights, outlining different levels of automation in radiotherapy and their impact on human involvement.
- Key risks of this automation include complacency and data overload, which necessitate strategies like checklists and proper training to ensure effective human-automation collaboration while maintaining the critical need for human oversight in complex clinical scenarios.*
Background And Purpose: Over the past decade, tools for automation of various sub-tasks in radiotherapy planning have been introduced, such as auto-contouring and auto-planning. The purpose of this study was to benchmark what degree of automation is possible.
Materials And Methods: A challenge to perform automated treatment planning for prostate and prostate bed radiotherapy was set up.
Background Frailty is a common syndrome affecting older people and puts them at risk of hospitalisation, needing care or death. First signs of frailty include reduced muscle strength and mobility decline. A key cause of mobility decline as we age is sarcopenia (age related reduction in muscle strength and mass).
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